Repair Osteochondral Tissues with Hydrogel Materials

The Problem

Osteochondral defects (OCDs) – joint damage extending from cartilage into the underlying bone – are characterized by pain, loss of function and osteoarthritis. Autograft-based surgeries remain the “gold standard” to treat OCDs of the knee and other joints but are limited by defect size as well as donor site morbidity and pain. As OCDs progress, total joint replacement is often required. Tissue engineering represents a promising alternative to heal OCDs of knees and other joints.

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What we are doing

The goal of our research is to develop a regenerative technology in which a synthetic scaffold based on inorganic-organic hydrogels directs associated cells to heal OCDs.

Publications on this research

Continuous gradient scaffolds for rapid screening of cell-material interactions and interfacial tissue engineering

Bailey, B.M.; Nail, L.N.; Grunlan, M.A. “Continuous gradient scaffolds for rapid screening of cell-material interactions and interfacial tissue engineering,” Acta Biomaterialia, 2013, 9, 8254-8261.

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PDMSstar-PEG hydrogels prepared via solvent-induced phase separation (SIPS) and their potential utility as tissue engineering scaffolds

Bailey, B.M.; Fei, R.; Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “PDMSstar-PEG hydrogels prepared via solvent-induced phase separation (SIPS) and their potential utility as tissue engineering scaffolds,” Acta Biomaterialia, 2012, 8, 4324-4333.

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Osteogenic potential of poly(ethylene glycol)-poly(dimethylsiloxane) hybrid hydrogels

Munoz-Pinto, D.; Jimenez-Vergara, A.; Hou, Y.; Hayenga, H.N., Grunlan, M.A.; Hahn, M.S. “Osteogenic potential of poly(ethylene glycol)-poly(dimethylsiloxane) hybrid hydrogels,” Tissue Eng. Part A 2012, 18, 1710-1719.

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Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS)

Bailey, B.M.; Hui, V.; Fei, R., Grunlan, M.A. “Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS),” J. Mater. Chem. 2011, 21, 18776-18782.

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Inorganic-organic hybrid scaffolds for osteochondral regeneration

Munoz-Pinto, D.J.; McMahon, R.E.; Kanzelberger, M.A.; Jimenez-Vergara, A.C.; Grunlan, M.A.; Hahn, M.S. “Inorganic-organic hybrid scaffolds for osteochondral regeneration,” J. Biomed. Mater. Res. Part A, 2010, 94, 112-121.

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Photo-crosslinked PDMSstar-PEG hydrogels: Synthesis, characterization, and potential application for tissue engineering scaffolds

Hou, Y.; Schoener, C.A.; Regan, K.R.; Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “Photo-crosslinked PDMSstar-PEG hydrogels: Synthesis, characterization, and potential application for tissue engineering scaffolds,” Biomacromolecules 2010, 11, 648-656.

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Interested in our work with Hydrogel Materials?

If you would like to talk with us more about our research or are interested in partnering with us in some way, get in touch and we will get back to you within 48 hours.
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