Repair of Bone Defects with Shape Memory Polymers

The Right Fit, the Best Healing

Cranio-maxillofacial (CMF) defects (as well as other types bone defects) can result from traumatic injury, infection, tumor removal or congenital bone disease. The current gold standard to treat CMF bone defects is with autografts, but these suffer from limited availability, complex harvesting procedures as well as donor site morbidity and pain. A particular difficulty is shaping and fixing the rigid autograft tightly into the defect so as to prevent resorption. Tissue engineering represents a promising alternative to heal CMF bone defects.

shape memory polymer

What we are doing

A foam that shapes to fit into defects of any shape offers the potential for improved repair of bone defects. For this, “self-fitting” scaffolds based on inorganic-organic shape memory polymer (SMP) foams are being researched.

Publications on this research

A bioactive “self-fitting” shape memory polymer (SMP) scaffold with potential to treat cranio- maxillofacial (CMF) bone defects

Zhang, D.; George, O.J.; Petersen, K.M.; Jimenez-Vergara, A.C.; Hahn, M.S. Grunlan, M.A. “A bioactive “self-fitting” shape memory polymer (SMP) scaffold with potential to treat cranio-
maxillofacial (CMF) bone defects,” Acta Biomaterialia, 2014, 10, 4597-4605.

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PDMS-PCL shape memory polymer (SMP) foams

Zhang, D.; Petersen, K.M.; Grunlan, M.A. “PDMS-PCL shape memory polymer (SMP) foams,” ACS Appl. Mater. & Interfaces. 2012, 5, 186-191.

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Porous inorganic-organic shape memory polymers

Zhang, D.; Burkes, W.L.; Schoener, C.A.; Grunlan, M.A. “Porous inorganic-organic shape memory polymers,” Polymer 2012, 53, 2935-2941.

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Polycaprolactone-based shape memory polymers with variable polydimethylsiloxane soft segments

Zhang, D.; Giese, M.L.; Prukop, S.L.; Grunlan, M.A. “Polycaprolactone-based shape memory polymers with variable polydimethylsiloxane soft segments,” J. Polym. Sci., Part A: Polym. Chem., 2010, 49, 754-761.

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Shape memory polymers with silicon-containing segments

Schoener, C.A.; Weyand, C.B.; Murthy, R.M.; Grunlan, M.A. “Shape memory polymers with silicon-containing segments,” J. Mater. Chem. 2010, 20, 1787-1793.

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Interested in our work on Shape Memory Polymers?

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