Anti-fouling Coatings for Medical Devices

Keeping devices "clean" for better performance

A variety of medical devices suffer diminished performance and complications due to adsorption of proteins from tissues such as the blood, subcutaneous tissue and eye.

What we are doing

Our research is directed at developing coating technologies to prevent protein adsorption and subsequent negative events on medical devices (e.g. clotting and infection). Towards this goal, we have developed “PEG-silane amphiphiles” that can be introduced during or after device manufacture.

Publications on this research

rotein resistance efficacy of PEO-silane amphiphiles: Dependence on PEO-segment length and concentration in silicone

Rufin, M.A.; Barry, M.A.; Adair, P.A.; Hawkins, M.L.; Raymond, J.E.; Grunlan, M.A.. “Protein resistance efficacy of PEO-silane amphiphiles: Dependence on PEO-segment length and concentration in silicone,” Acta Biomaterialia, 2016, 41, 247-252.

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Enhancing the protein resistance of silicone via surface-restructuring PEO-silane amphiphiles with variable PEO length

Rufin, M.A.; Gruetzner, J.A.; Hurley, M.J.; Hawkins, M.L.; Raymond, E.S.; Raymond, J.E.; Grunlan, M.A. "Enhancing the protein resistance of silicone via surface-restructuring PEO-silane amphiphiles with variable PEO length," J. Mater. Chem. B. 2015, 3, 2816-2825.

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Direct observation of the nanocomplex reorganization of antifouling silicones containing a highly mobile PEO-silane amphiphile

Hawkins, M.L.; Rufin, M.A.; Raymond, J.E.; Grunlan, M.A. “Direct observation of the nanocomplex reorganization of antifouling silicones containing a highly mobile PEO-silane amphiphile,” J. Mater. Chem. Part B, 2014, 2, 5689-5697.

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Protein resistance of silicones prepared with a PEO-silane amphiphile

Hawkins, M.L.; Grunlan, M.A. “Protein resistance of silicones prepared with a PEO-silane amphiphile,” J. Mater. Chem. 2012, 22, 19540-19546.

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Amphiphilic silicones prepared with branched PEO-silanes with siloxane tethers

Murthy, R.; Bailey, B.M.; Valentin-Rodriguez, C.; Ivanisevic, A.; Grunlan, M.A. “Amphiphilic silicones prepared with branched PEO-silanes with siloxane tethers,” J. Polym. Sci., Part A: Polym. Chem., 2010, 48, 4108-4119.

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The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption

Murthy, R.; Shell, C.E.; Grunlan, M.A. “The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption” Biomaterials 2009, 30, 2433-2439.

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Protein-resistant silicones: Incorporation of poly(ethylene oxide) via siloxane tethers

Murthy, R.; Cox, C.D.; Hahn, M.S.; Grunlan, M.A. “Protein-resistant silicones: Incorporation of poly(ethylene oxide) via siloxane tethers,” Biomacromolecules, 2007, 8, 3244-3252.

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Interested in our work on Anti-fouling Coatings for Medical Devices?

If you would like to talk with us more about our research or are interested in partnering with us in some way, get in touch and we will get back to you within 48 hours.
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